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KMID : 0043320120350101779
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Archives of Pharmacal Research
2012 Volume.35 No. 10 p.1779 ~ p.1784
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Two new hemiterpene glycosides from the leaves of Ilex rotunda. thunb
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Kim Manh-Heun
Park Kwan-Hee
Oh Myeong-Hwan
Kim Han-Hyuk
Choe Kang-In
Park Sang-Hee
Lee Min-Won
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Abstract
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Chromatographic separation of the 80% MeOH extract of the leaves of Ilex rotunda (IR) led to isolation of two new hemiterpene glycosides, tentatively named as rotundarpenoside A (1) and rotundarpenoside B (2), along with five known caffeoyl derivatives (3?7). The chemical structures of these compounds were elucidated using 1D/2D NMR, HR-MS, and the absolute configuration was confirmed by Mosher’s method. In order to evaluate their anti-oxidative activities, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and xanthine oxidase superoxide scavenging activities (NBT) were determined.
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KEYWORD
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Ilex rotunda, Hemiterpenes, Caffeoylquinic acids, Anti-oxidative activity
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